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EXALGO vs VANTRELA ER

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. EXALGO and VANTRELA ER are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
New

Pharmacy pays

$0.57 /mL
~$239.83 /30

Type

RX
RX

Active ingredient

HYDROMORPHONE HYDROCHLORIDE
HYDROCODONE BITARTRATE

Dosage forms

Tablet, extended release
Tablet, extended release

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

None
None

Half-life

about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid
about 3.8 hours (3.8 ± 0.3 hours)

Treats

Cough, Postoperative Pain
Cough, Obstructive Lung Diseases, Postoperative Pain

Frequently asked questions

What is the difference between Exalgo and Vantrela ER?

Exalgo contains Hydromorphone Hydrochloride, while Vantrela ER contains Hydrocodone Bitartrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.