EXALGO vs ULTIVA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. EXALGO and ULTIVA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	EXALGO	ULTIVA
Rating	70/100	70/100
Pharmacy pays	$0.57 /mL	—
Type	RX	RX
Active ingredient	HYDROMORPHONE HYDROCHLORIDE	REMIFENTANIL HYDROCHLORIDE
Manufacturer	Specgx LLC	Mylan Institutional
Dosage forms	Tablet, extended release	Injectable
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	Boxed warning
Half-life	about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid	—
Treats	Cough, Postoperative Pain	Pain

exalgo ultiva

Rating

70/100

Pharmacy pays

$0.57 /mL

—

Type

Active ingredient

HYDROMORPHONE HYDROCHLORIDE

REMIFENTANIL HYDROCHLORIDE

Manufacturer

Specgx LLC

Mylan Institutional

Dosage forms

Tablet, extended release

Injectable

Drug class

Opioid Agonist

Boxed warning

None

Boxed warning

Half-life

about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid

—

Treats

Cough, Postoperative Pain

Pain

Frequently asked questions

Which is better-rated, Exalgo or Ultiva?

Exalgo and Ultiva are tied at 3.5 out of 5 by our independent rating.

What is the difference between Exalgo and Ultiva?

Exalgo contains Hydromorphone Hydrochloride, while Ultiva contains Remifentanil Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.