EXALGO vs RYZOLT
Independent side-by-side comparison.
Possible drug interaction. EXALGO and RYZOLT are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.
Rating
70/100
New
Pharmacy pays
$0.57 /mL
~$0.72 /30
Type
RX
RX
Active ingredient
HYDROMORPHONE HYDROCHLORIDE
TRAMADOL HYDROCHLORIDE
Manufacturer
Dosage forms
Tablet, extended release
Tablet, extended release
Drug class
Opioid Agonist
Opioid Agonist
Boxed warning
None
None
Half-life
about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid
about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)
Treats
Cough, Postoperative Pain
Pain
Frequently asked questions
What is the difference between Exalgo and Ryzolt?
Exalgo contains Hydromorphone Hydrochloride, while Ryzolt contains Tramadol Hydrochloride — they have different active ingredients.
Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.