EXALGO vs ROXICODONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. EXALGO and ROXICODONE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	EXALGO	ROXICODONE
Rating	70/100	New
Pharmacy pays	$0.57 /mL	$0.08 /mL
Type	RX	RX
Active ingredient	HYDROMORPHONE HYDROCHLORIDE	OXYCODONE HYDROCHLORIDE
Manufacturer	Specgx LLC	Roxane
Dosage forms	Tablet, extended release	Tablet
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid	about 3.5 to 4 hours
Treats	Cough, Postoperative Pain	Postoperative Pain

exalgo roxicodone

Rating

70/100

New

Pharmacy pays

$0.57 /mL

$0.08 /mL

Type

Active ingredient

HYDROMORPHONE HYDROCHLORIDE

OXYCODONE HYDROCHLORIDE

Manufacturer

Specgx LLC

Roxane

Dosage forms

Tablet, extended release

Tablet

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid

about 3.5 to 4 hours

Treats

Cough, Postoperative Pain

Postoperative Pain

Frequently asked questions

Which is cheaper, Exalgo or Roxicodone?

Roxicodone costs pharmacies less to acquire — about $0.08 vs $0.57 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Exalgo and Roxicodone?

Exalgo contains Hydromorphone Hydrochloride, while Roxicodone contains Oxycodone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.