EXALGO vs OXYCONTIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. EXALGO and OXYCONTIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	EXALGO	OXYCONTIN
Rating	70/100	New
Pharmacy pays	$0.57 /mL	$0.08 /mL
Type	RX	RX
Active ingredient	HYDROMORPHONE HYDROCHLORIDE	OXYCODONE HYDROCHLORIDE
Manufacturer	Specgx LLC	Knoa Pharma
Dosage forms	Tablet, extended release	Tablet, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	Boxed warning
Half-life	about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid	about 3.5 to 4 hours
Treats	Cough, Postoperative Pain	Postoperative Pain

exalgo oxycontin

Rating

70/100

New

Pharmacy pays

$0.57 /mL

$0.08 /mL

Type

Active ingredient

HYDROMORPHONE HYDROCHLORIDE

OXYCODONE HYDROCHLORIDE

Manufacturer

Specgx LLC

Knoa Pharma

Dosage forms

Tablet, extended release

Drug class

Opioid Agonist

Boxed warning

None

Boxed warning

Half-life

about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid

about 3.5 to 4 hours

Treats

Cough, Postoperative Pain

Postoperative Pain

Frequently asked questions

Which is cheaper, Exalgo or Oxycontin?

Oxycontin costs pharmacies less to acquire — about $0.08 vs $0.57 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Exalgo and Oxycontin?

Exalgo contains Hydromorphone Hydrochloride, while Oxycontin contains Oxycodone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.