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EXALGO vs IMODIUM A-D EZ CHEWS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. EXALGO and IMODIUM A-D EZ CHEWS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

exalgoimodium a-d ez chews

Rating

70/100
New

Pharmacy pays

$0.57 /mL
$0.05 /mL

Type

RX
RX

Active ingredient

HYDROMORPHONE HYDROCHLORIDE
LOPERAMIDE HYDROCHLORIDE

Manufacturer

Specgx LLC
J and J Consumer Inc

Dosage forms

Tablet, extended release
Tablet, chewable

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

None
None

Half-life

about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid
about 10.8 hours (range 9.1 to 14.4 hours)

Treats

Cough, Postoperative Pain
Functional Colonic Diseases, Diarrhea, Bacillary Dysentery

Frequently asked questions

Which is cheaper, Exalgo or Imodium A-D Ez Chews?

Imodium A-D Ez Chews costs pharmacies less to acquire — about $0.05 vs $0.57 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Exalgo and Imodium A-D Ez Chews?

Exalgo contains Hydromorphone Hydrochloride, while Imodium A-D Ez Chews contains Loperamide Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.