EXALGO vs IMODIUM A-D

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Attribute	EXALGO	IMODIUM A-D
Rating	70/100	70/100
Pharmacy pays	$0.57 /mL	$0.05 /mL
Type	RX	OTC
Active ingredient	HYDROMORPHONE HYDROCHLORIDE	LOPERAMIDE HYDROCHLORIDE
Manufacturer	Specgx LLC	Kenvue Brands
Dosage forms	Tablet, extended release	Capsule, Solution, Tablet
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid	about 10.8 hours (range 9.1 to 14.4 hours)
Treats	Cough, Postoperative Pain	Functional Colonic Diseases, Diarrhea, Bacillary Dysentery

exalgo imodium a-d

Rating

70/100

Pharmacy pays

$0.57 /mL

$0.05 /mL

Type

OTC

Active ingredient

HYDROMORPHONE HYDROCHLORIDE

LOPERAMIDE HYDROCHLORIDE

Manufacturer

Specgx LLC

Kenvue Brands

Dosage forms

Tablet, extended release

Capsule, Solution, Tablet

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid

about 10.8 hours (range 9.1 to 14.4 hours)

Treats

Cough, Postoperative Pain

Functional Colonic Diseases, Diarrhea, Bacillary Dysentery

Get imodium a-d

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Frequently asked questions

Which is better-rated, Exalgo or Imodium A-D?

Exalgo and Imodium A-D are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Exalgo or Imodium A-D?

Imodium A-D costs pharmacies less to acquire — about $0.05 vs $0.57 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Exalgo and Imodium A-D?

Exalgo contains Hydromorphone Hydrochloride, while Imodium A-D contains Loperamide Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.