EXALGO vs FENTANYL-12

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. EXALGO and FENTANYL-12 are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	EXALGO	FENTANYL-12
Rating	70/100	New
Pharmacy pays	$0.57 /mL	$9.51 /mL
Type	RX	RX
Active ingredient	HYDROMORPHONE HYDROCHLORIDE	FENTANYL
Manufacturer	Specgx LLC	Mylan Technologies
Dosage forms	Tablet, extended release	Patch
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	Boxed warning
Half-life	about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid	—
Treats	Cough, Postoperative Pain	Pain

exalgo fentanyl-12

Rating

70/100

New

Pharmacy pays

$0.57 /mL

$9.51 /mL

Type

Active ingredient

HYDROMORPHONE HYDROCHLORIDE

FENTANYL

Manufacturer

Specgx LLC

Mylan Technologies

Dosage forms

Tablet, extended release

Patch

Drug class

Opioid Agonist

Boxed warning

None

Boxed warning

Half-life

about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid

—

Treats

Cough, Postoperative Pain

Pain

Frequently asked questions

Which is cheaper, Exalgo or Fentanyl-12?

Exalgo costs pharmacies less to acquire — about $0.57 vs $9.51 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Exalgo and Fentanyl-12?

Exalgo contains Hydromorphone Hydrochloride, while Fentanyl-12 contains Fentanyl — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.