EVEKEO ODT vs METHYLIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. EVEKEO ODT and METHYLIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	EVEKEO ODT	METHYLIN
Rating	70/100	70/100
Pharmacy pays	~$478.55 /30	~$18.94 /30
Type	RX	RX
Active ingredient	AMPHETAMINE SULFATE	METHYLPHENIDATE HYDROCHLORIDE
Manufacturer	Azurity	Specgx LLC
Dosage forms	Tablet, orally disintegrating	Solution
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	None	Boxed warning
Half-life	about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults	about 2.7 hours
Treats	Attention Deficit Disorder with Hyperactivity, Narcolepsy	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

evekeo odt methylin

Rating

70/100

Pharmacy pays

~$478.55 /30

~$18.94 /30

Type

Active ingredient

AMPHETAMINE SULFATE

METHYLPHENIDATE HYDROCHLORIDE

Manufacturer

Azurity

Specgx LLC

Dosage forms

Tablet, orally disintegrating

Solution

Drug class

Central Nervous System Stimulant

Boxed warning

None

Boxed warning

Half-life

about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults

about 2.7 hours

Treats

Attention Deficit Disorder with Hyperactivity, Narcolepsy

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

Frequently asked questions

Which is better-rated, Evekeo ODT or Methylin?

Evekeo ODT and Methylin are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Evekeo ODT or Methylin?

Methylin costs pharmacies less to acquire — about $18.94 vs $478.55 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Evekeo ODT and Methylin?

Evekeo ODT contains Amphetamine Sulfate, while Methylin contains Methylphenidate Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.