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ESTROGEL vs VAGIFEM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Rating

New
70/100

Pharmacy pays

$6.55 /g
$6.55 /g

Type

RX
RX

Active ingredient

ESTRADIOL
ESTRADIOL

Dosage forms

Topical, metered
Insert

Drug class

Estrogen
Estrogen

Treats

Breast Neoplasms, Hypogonadism, Premature Menopause
Breast Neoplasms, Hypogonadism, Premature Menopause

Frequently asked questions

Which is cheaper, Estrogel or Vagifem?

Pharmacies pay about the same to acquire either one — roughly $6.55 per gm, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Estrogel and Vagifem?

Both Estrogel and Vagifem share the active ingredient Estradiol.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.