ESTROGEL vs PREMARIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. ESTROGEL and PREMARIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ESTROGEL	PREMARIN
Rating	New	New
Pharmacy pays	$6.55 /g	—
Type	RX	RX
Active ingredient	ESTRADIOL	ESTROGENS, CONJUGATED
Manufacturer	Ascend Theraps US	Wyeth Pharms Inc
Dosage forms	Topical, metered	Tablet
Drug class	Estrogen	Estrogen
Boxed warning	Boxed warning	Boxed warning
Treats	Breast Neoplasms, Hypogonadism, Premature Menopause	—

estrogel premarin

Rating

New

Pharmacy pays

$6.55 /g

—

Type

Active ingredient

ESTRADIOL

ESTROGENS, CONJUGATED

Manufacturer

Ascend Theraps US

Wyeth Pharms Inc

Dosage forms

Topical, metered

Tablet

Drug class

Estrogen

Boxed warning

Treats

Breast Neoplasms, Hypogonadism, Premature Menopause

—

Frequently asked questions

What is the difference between Estrogel and Premarin?

Estrogel contains Estradiol, while Premarin contains Estrogens, Conjugated — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.