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ESOMEPRAZOLE SODIUM vs PANTOPRAZOLE SODIUM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. ESOMEPRAZOLE SODIUM and PANTOPRAZOLE SODIUM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
New

Pharmacy pays

~$177.68 /30
~$120.76 /30

Type

RX
RX

Active ingredient

ESOMEPRAZOLE SODIUM
PANTOPRAZOLE SODIUM

Dosage forms

Injectable, Powder
Powder, delayed release, Injectable, Solution, Powder, Tablet, delayed release

Drug class

Proton Pump Inhibitor
Proton Pump Inhibitor

Boxed warning

None
None

Half-life

about 1 hour

Treats

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux
Esophagitis, Gastroesophageal Reflux, Heartburn

Frequently asked questions

Which is cheaper, Esomeprazole Sodium or Pantoprazole Sodium?

Pantoprazole Sodium costs pharmacies less to acquire — about $120.76 vs $177.68 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Esomeprazole Sodium and Pantoprazole Sodium?

Esomeprazole Sodium contains Esomeprazole Sodium, while Pantoprazole Sodium contains Pantoprazole Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.