ESOMEPRAZOLE SODIUM vs NEXIUM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. ESOMEPRAZOLE SODIUM and NEXIUM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ESOMEPRAZOLE SODIUM	NEXIUM
Rating	New	70/100
Pharmacy pays	~$177.68 /30	—
Type	RX	RX
Active ingredient	ESOMEPRAZOLE SODIUM	ESOMEPRAZOLE MAGNESIUM
Manufacturer	Sun Pharm	Astrazeneca
Dosage forms	Injectable, Powder	Capsule, delayed release, Powder, delayed release
Drug class	Proton Pump Inhibitor	Proton Pump Inhibitor
Boxed warning	None	None
Treats	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

esomeprazole sodium nexium

Rating

New

70/100

Pharmacy pays

~$177.68 /30

—

Type

Active ingredient

ESOMEPRAZOLE SODIUM

ESOMEPRAZOLE MAGNESIUM

Manufacturer

Sun Pharm

Astrazeneca

Dosage forms

Injectable, Powder

Capsule, delayed release, Powder, delayed release

Drug class

Proton Pump Inhibitor

Boxed warning

None

Treats

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

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Frequently asked questions

What is the difference between Esomeprazole Sodium and Nexium?

Esomeprazole Sodium contains Esomeprazole Sodium, while Nexium contains Esomeprazole Magnesium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.