ESOMEPRAZOLE MAGNESIUM vs PRILOSEC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. ESOMEPRAZOLE MAGNESIUM and PRILOSEC are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ESOMEPRAZOLE MAGNESIUM	PRILOSEC
Rating	66/100	70/100
Pharmacy pays	—	~$1.52 /30
Type	RX	RX
Active ingredient	ESOMEPRAZOLE MAGNESIUM	OMEPRAZOLE
Manufacturer	Mylan	Astrazeneca
Dosage forms	Capsule, delayed release, Powder, extended release	Powder, delayed release
Drug class	Proton Pump Inhibitor	Proton Pump Inhibitor
Boxed warning	None	None
Half-life	—	about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults
Treats	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

esomeprazole magnesium prilosec

Rating

66/100

70/100

Pharmacy pays

—

~$1.52 /30

Type

Active ingredient

ESOMEPRAZOLE MAGNESIUM

OMEPRAZOLE

Manufacturer

Mylan

Astrazeneca

Dosage forms

Capsule, delayed release, Powder, extended release

Powder, delayed release

Drug class

Proton Pump Inhibitor

Boxed warning

None

Half-life

—

about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults

Treats

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

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Frequently asked questions

Which is better-rated, Esomeprazole Magnesium or Prilosec?

By our independent rating, Prilosec scores higher — 3.5 vs 3.3 out of 5 for Esomeprazole Magnesium. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Esomeprazole Magnesium and Prilosec?

Esomeprazole Magnesium contains Esomeprazole Magnesium, while Prilosec contains Omeprazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.