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ESOMEPRAZOLE MAGNESIUM vs OMEPRAZOLE MAGNESIUM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. ESOMEPRAZOLE MAGNESIUM and OMEPRAZOLE MAGNESIUM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

66/100
68/100

Pharmacy pays

Type

RX
RX

Active ingredient

ESOMEPRAZOLE MAGNESIUM
OMEPRAZOLE MAGNESIUM

Dosage forms

Capsule, delayed release, Powder, extended release
Capsule, delayed release

Drug class

Proton Pump Inhibitor
Proton Pump Inhibitor

Boxed warning

None
None

Half-life

about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults

Treats

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux
Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

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Frequently asked questions

Which is better-rated, Esomeprazole Magnesium or Omeprazole Magnesium?

By our independent rating, Omeprazole Magnesium scores higher — 3.4 vs 3.3 out of 5 for Esomeprazole Magnesium. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Esomeprazole Magnesium and Omeprazole Magnesium?

Esomeprazole Magnesium contains Esomeprazole Magnesium, while Omeprazole Magnesium contains Omeprazole Magnesium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.