ESBRIET vs MYSOLINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 5, 2026·How we rate

Possible drug interaction. ESBRIET and MYSOLINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ESBRIET	MYSOLINE
Rating	New	74/100
Pharmacy pays	~$45.48 /30	~$2.89 /30
Type	RX	RX
Active ingredient	PIRFENIDONE	PRIMIDONE
Manufacturer	Legacy Pharma	Valeant Pharm Intl
Dosage forms	Tablet	Tablet
Drug class	Pyridone	Anti-Epileptic Agent
Boxed warning	None	None
Treats	Pulmonary Fibrosis	Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

esbriet mysoline

Rating

New

74/100

Pharmacy pays

~$45.48 /30

~$2.89 /30

Type

Active ingredient

PIRFENIDONE

PRIMIDONE

Manufacturer

Legacy Pharma

Valeant Pharm Intl

Dosage forms

Tablet

Drug class

Pyridone

Anti-Epileptic Agent

Boxed warning

None

Treats

Pulmonary Fibrosis

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

Frequently asked questions

Which is cheaper, Esbriet or Mysoline?

Mysoline costs pharmacies less to acquire — about $2.89 vs $45.48 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Esbriet and Mysoline?

Esbriet contains Pirfenidone, while Mysoline contains Primidone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.