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EPSOLAY vs RETIN-A

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 15, 2026·How we rate

Possible drug interaction. EPSOLAY and RETIN-A are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
70/100

Pharmacy pays

$0.05 /g
$1.05 /g

Type

RX
RX

Active ingredient

BENZOYL PEROXIDE
TRETINOIN

Dosage forms

Topical
Topical

Drug class

Retinoid

Boxed warning

None
None

Treats

Acne Vulgaris, Rosacea
Acne Vulgaris, Facial Dermatoses, Acute Promyelocytic Leukemia

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Frequently asked questions

Which is better-rated, Epsolay or Retin-A?

Epsolay and Retin-A are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Epsolay or Retin-A?

Epsolay costs pharmacies less to acquire — about $0.05 vs $1.05 per gm, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Epsolay and Retin-A?

Epsolay contains Benzoyl Peroxide, while Retin-A contains Tretinoin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.