ELIQUIS vs XARELTO

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. ELIQUIS and XARELTO are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ELIQUIS	XARELTO
Rating	New	70/100
Pharmacy pays	—	$0.98 /mL
Type	RX	RX
Active ingredient	APIXABAN	RIVAROXABAN
Manufacturer	Bristol	Janssen Pharms
Dosage forms	Tablet	Powder, Tablet, Kit
Drug class	Factor Xa Inhibitor	Factor Xa Inhibitor
Boxed warning	None	Boxed warning
Half-life	about 12 hours	about 5 to 9 hours (11 to 13 hours in older adults)
Treats	Pulmonary Embolism, Venous Thrombosis	Pulmonary Embolism, Venous Thrombosis

eliquis xarelto

Rating

New

70/100

Pharmacy pays

—

$0.98 /mL

Type

Active ingredient

APIXABAN

RIVAROXABAN

Manufacturer

Bristol

Janssen Pharms

Dosage forms

Tablet

Powder, Tablet, Kit

Drug class

Factor Xa Inhibitor

Boxed warning

None

Boxed warning

Half-life

about 12 hours

about 5 to 9 hours (11 to 13 hours in older adults)

Treats

Pulmonary Embolism, Venous Thrombosis

Frequently asked questions

What is the difference between Eliquis and Xarelto?

Eliquis contains Apixaban, while Xarelto contains Rivaroxaban — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.