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ELIDEL vs PROTOPIC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. ELIDEL and PROTOPIC are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
New

Pharmacy pays

$3.19 /g
$0.65 /g

Type

RX
RX

Active ingredient

PIMECROLIMUS
TACROLIMUS

Dosage forms

Topical
Topical

Drug class

Calcineurin Inhibitor Immunosuppressant
Calcineurin Inhibitor Immunosuppressant

Boxed warning

Treats

Atopic Dermatitis
Atopic Dermatitis, Graft Vs Host Disease

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Frequently asked questions

Which is cheaper, Elidel or Protopic?

Protopic costs pharmacies less to acquire — about $0.65 vs $3.19 per gm, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Elidel and Protopic?

Elidel contains Pimecrolimus, while Protopic contains Tacrolimus — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.