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EFUDEX vs TOLAK

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Rating

New
72/100

Pharmacy pays

$0.61 /mL
$0.61 /mL

Type

RX
RX

Active ingredient

FLUOROURACIL
FLUOROURACIL

Dosage forms

Topical
Topical

Drug class

Nucleoside Metabolic Inhibitor
Nucleoside Metabolic Inhibitor

Boxed warning

None
None

Treats

Breast Neoplasms, Basal Cell Carcinoma, Colonic Neoplasms
Breast Neoplasms, Basal Cell Carcinoma, Colonic Neoplasms

Frequently asked questions

Which is cheaper, Efudex or Tolak?

Pharmacies pay about the same to acquire either one — roughly $0.61 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Efudex and Tolak?

Both Efudex and Tolak share the active ingredient Fluorouracil.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.