EFUDEX vs ONUREG

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. EFUDEX and ONUREG are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	EFUDEX	ONUREG
Rating	New	New
Pharmacy pays	$0.61 /mL	—
Type	RX	RX
Active ingredient	FLUOROURACIL	AZACITIDINE
Manufacturer	Extrovis	Bristol
Dosage forms	Topical	Tablet
Drug class	Nucleoside Metabolic Inhibitor	Nucleoside Metabolic Inhibitor
Boxed warning	None	None
Treats	Breast Neoplasms, Basal Cell Carcinoma, Colonic Neoplasms	Refractory Anemia, Sideroblastic Anemia, Chronic Myelomonocytic Leukemia

efudex onureg

Rating

New

Pharmacy pays

$0.61 /mL

—

Type

Active ingredient

FLUOROURACIL

AZACITIDINE

Manufacturer

Extrovis

Bristol

Dosage forms

Topical

Tablet

Drug class

Nucleoside Metabolic Inhibitor

Boxed warning

None

Treats

Breast Neoplasms, Basal Cell Carcinoma, Colonic Neoplasms

Refractory Anemia, Sideroblastic Anemia, Chronic Myelomonocytic Leukemia

Frequently asked questions

What is the difference between Efudex and Onureg?

Efudex contains Fluorouracil, while Onureg contains Azacitidine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.