EFFEXOR XR vs FETZIMA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. EFFEXOR XR and FETZIMA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	EFFEXOR XR	FETZIMA
Rating	New	72/100
Pharmacy pays	~$3.59 /30	—
Type	RX	RX
Active ingredient	VENLAFAXINE HYDROCHLORIDE	LEVOMILNACIPRAN HYDROCHLORIDE
Manufacturer	Upjohn	Abbvie
Dosage forms	Capsule, extended release	Capsule, extended release, Kit
Drug class	Serotonin and Norepinephrine Reuptake Inhibitor	Serotonin and Norepinephrine Reuptake Inhibitor
Boxed warning	Boxed warning	Boxed warning
Half-life	about 5 hours (mean roughly 5 ± 2 hours) for the parent drug venlafaxine in adults with normal organ function	about 12 hours
Treats	Attention Deficit Disorder with Hyperactivity, Autistic Disorder, Depressive Disorder	Major Depressive Disorder

effexor xr fetzima

Rating

New

72/100

Pharmacy pays

~$3.59 /30

—

Type

Active ingredient

VENLAFAXINE HYDROCHLORIDE

LEVOMILNACIPRAN HYDROCHLORIDE

Manufacturer

Upjohn

Abbvie

Dosage forms

Capsule, extended release

Capsule, extended release, Kit

Drug class

Serotonin and Norepinephrine Reuptake Inhibitor

Boxed warning

Half-life

about 5 hours (mean roughly 5 ± 2 hours) for the parent drug venlafaxine in adults with normal organ function

about 12 hours

Treats

Attention Deficit Disorder with Hyperactivity, Autistic Disorder, Depressive Disorder

Major Depressive Disorder

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Frequently asked questions

What is the difference between Effexor XR and Fetzima?

Effexor XR contains Venlafaxine Hydrochloride, while Fetzima contains Levomilnacipran Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.