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EC-NAPROSYN vs MOTRIN MIGRAINE PAIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. EC-NAPROSYN and MOTRIN MIGRAINE PAIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
70/100

Pharmacy pays

$0.06 /mL
$0.04 /mL

Type

RX
RX

Active ingredient

NAPROXEN
IBUPROFEN

Dosage forms

Tablet, delayed release
Tablet

Drug class

Nonsteroidal Anti-Inflammatory Drug
Nonsteroidal Anti-Inflammatory Drug

Boxed warning

Half-life

about 12 to 17 hours
about 1.8 to 2.0 hours

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Back Pain
Juvenile Arthritis, Rheumatoid Arthritis, Bursitis

Frequently asked questions

Which is cheaper, Ec-Naprosyn or Motrin Migraine Pain?

Motrin Migraine Pain costs pharmacies less to acquire — about $0.04 vs $0.06 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Ec-Naprosyn and Motrin Migraine Pain?

Ec-Naprosyn contains Naproxen, while Motrin Migraine Pain contains Ibuprofen — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.