DYRENIUM vs HYDROCHLOROTHIAZIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. DYRENIUM and HYDROCHLOROTHIAZIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DYRENIUM	HYDROCHLOROTHIAZIDE
Rating	New	72/100
Pharmacy pays	~$211.37 /30	~$0.91 /30
Type	RX	RX
Active ingredient	TRIAMTERENE	HYDROCHLOROTHIAZIDE
Manufacturer	Advanz Pharma	Unichem
Dosage forms	Capsule	Capsule, Tablet
Drug class	Potassium-Sparing Diuretic	Thiazide Diuretic
Boxed warning	Boxed warning	None
Half-life	—	about 6 to 15 hours (the label reports a range, not a single number)
Treats	Edema, Hypertension, Hypokalemia	Edema, Heart Failure, Hypertension

dyrenium hydrochlorothiazide

Rating

New

72/100

Pharmacy pays

~$211.37 /30

~$0.91 /30

Type

Active ingredient

TRIAMTERENE

HYDROCHLOROTHIAZIDE

Manufacturer

Advanz Pharma

Unichem

Dosage forms

Capsule

Capsule, Tablet

Drug class

Potassium-Sparing Diuretic

Thiazide Diuretic

Boxed warning

None

Half-life

—

about 6 to 15 hours (the label reports a range, not a single number)

Treats

Edema, Hypertension, Hypokalemia

Edema, Heart Failure, Hypertension

Get hydrochlorothiazidehigher-rated option

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Frequently asked questions

Which is cheaper, Dyrenium or Hydrochlorothiazide?

Hydrochlorothiazide costs pharmacies less to acquire — about $0.91 vs $211.37 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Dyrenium and Hydrochlorothiazide?

Dyrenium contains Triamterene, while Hydrochlorothiazide contains Hydrochlorothiazide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.