DYRENIUM vs GUANFACINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. DYRENIUM and GUANFACINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DYRENIUM	GUANFACINE HYDROCHLORIDE
Rating	New	72/100
Pharmacy pays	~$211.37 /30	~$5.26 /30
Type	RX	RX
Active ingredient	TRIAMTERENE	GUANFACINE HYDROCHLORIDE
Manufacturer	Advanz Pharma	Actavis Elizabeth
Dosage forms	Capsule	Tablet
Drug class	Potassium-Sparing Diuretic	Central Alpha-2 Adrenergic Agonist
Boxed warning	Boxed warning	None
Treats	Edema, Hypertension, Hypokalemia	Attention Deficit Disorder with Hyperactivity, Hypertension

dyrenium guanfacine hydrochloride

Rating

New

72/100

Pharmacy pays

~$211.37 /30

~$5.26 /30

Type

Active ingredient

TRIAMTERENE

GUANFACINE HYDROCHLORIDE

Manufacturer

Advanz Pharma

Actavis Elizabeth

Dosage forms

Capsule

Tablet

Drug class

Potassium-Sparing Diuretic

Central Alpha-2 Adrenergic Agonist

Boxed warning

None

Treats

Edema, Hypertension, Hypokalemia

Attention Deficit Disorder with Hyperactivity, Hypertension

Get guanfacine hydrochloridehigher-rated option

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Frequently asked questions

Which is cheaper, Dyrenium or Guanfacine Hydrochloride?

Guanfacine Hydrochloride costs pharmacies less to acquire — about $5.26 vs $211.37 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Dyrenium and Guanfacine Hydrochloride?

Dyrenium contains Triamterene, while Guanfacine Hydrochloride contains Guanfacine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.