DURAMORPH PF vs RYZOLT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. DURAMORPH PF and RYZOLT are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DURAMORPH PF	RYZOLT
Rating	70/100	New
Pharmacy pays	$2.61 /mL	~$0.72 /30
Type	RX	RX
Active ingredient	MORPHINE SULFATE	TRAMADOL HYDROCHLORIDE
Manufacturer	Hikma	Purdue Pharma
Dosage forms	Injectable, Solution	Tablet, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	Boxed warning	None
Half-life	about 2 hours	about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)
Treats	Dyspnea, Intractable Pain	Pain

duramorph pf ryzolt

Rating

70/100

New

Pharmacy pays

$2.61 /mL

~$0.72 /30

Type

Active ingredient

MORPHINE SULFATE

TRAMADOL HYDROCHLORIDE

Manufacturer

Hikma

Purdue Pharma

Dosage forms

Injectable, Solution

Tablet, extended release

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 2 hours

about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)

Treats

Dyspnea, Intractable Pain

Pain

Frequently asked questions

What is the difference between Duramorph Pf and Ryzolt?

Duramorph Pf contains Morphine Sulfate, while Ryzolt contains Tramadol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.