DURAMORPH PF vs NUCYNTA ER

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. DURAMORPH PF and NUCYNTA ER are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DURAMORPH PF	NUCYNTA ER
Rating	70/100	New
Pharmacy pays	$2.61 /mL	~$335.93 /30
Type	RX	RX
Active ingredient	MORPHINE SULFATE	TAPENTADOL HYDROCHLORIDE
Manufacturer	Hikma	Collegium Pharm Inc
Dosage forms	Injectable, Solution	Tablet, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	Boxed warning	Boxed warning
Half-life	about 2 hours	about 5 hours (terminal half-life, on average, after oral administration)
Treats	Dyspnea, Intractable Pain	Pain

duramorph pf nucynta er

Rating

70/100

New

Pharmacy pays

$2.61 /mL

~$335.93 /30

Type

Active ingredient

MORPHINE SULFATE

TAPENTADOL HYDROCHLORIDE

Manufacturer

Hikma

Collegium Pharm Inc

Dosage forms

Injectable, Solution

Tablet, extended release

Drug class

Opioid Agonist

Boxed warning

Half-life

about 2 hours

about 5 hours (terminal half-life, on average, after oral administration)

Treats

Dyspnea, Intractable Pain

Pain

Frequently asked questions

What is the difference between Duramorph Pf and Nucynta ER?

Duramorph Pf contains Morphine Sulfate, while Nucynta ER contains Tapentadol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.