DURAMORPH PF vs LOPERAMIDE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. DURAMORPH PF and LOPERAMIDE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DURAMORPH PF	LOPERAMIDE HYDROCHLORIDE
Rating	70/100	70/100
Pharmacy pays	$2.61 /mL	$0.05 /mL
Type	RX	RX
Active ingredient	MORPHINE SULFATE	LOPERAMIDE HYDROCHLORIDE
Manufacturer	Hikma	Jubilant Cadista
Dosage forms	Injectable, Solution	Capsule
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	Boxed warning	Boxed warning
Half-life	about 2 hours	about 10.8 hours (range 9.1 to 14.4 hours)
Treats	Dyspnea, Intractable Pain	Functional Colonic Diseases, Diarrhea, Bacillary Dysentery

duramorph pf loperamide hydrochloride

Rating

70/100

Pharmacy pays

$2.61 /mL

$0.05 /mL

Type

Active ingredient

MORPHINE SULFATE

LOPERAMIDE HYDROCHLORIDE

Manufacturer

Hikma

Jubilant Cadista

Dosage forms

Injectable, Solution

Capsule

Drug class

Opioid Agonist

Boxed warning

Half-life

about 2 hours

about 10.8 hours (range 9.1 to 14.4 hours)

Treats

Dyspnea, Intractable Pain

Functional Colonic Diseases, Diarrhea, Bacillary Dysentery

Frequently asked questions

Which is better-rated, Duramorph Pf or Loperamide Hydrochloride?

Duramorph Pf and Loperamide Hydrochloride are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Duramorph Pf or Loperamide Hydrochloride?

Loperamide Hydrochloride costs pharmacies less to acquire — about $0.05 vs $2.61 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Duramorph Pf and Loperamide Hydrochloride?

Duramorph Pf contains Morphine Sulfate, while Loperamide Hydrochloride contains Loperamide Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.