DURAMORPH PF vs EXALGO

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 15, 2026·How we rate

Possible drug interaction. DURAMORPH PF and EXALGO are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DURAMORPH PF	EXALGO
Rating	70/100	70/100
Pharmacy pays	$2.61 /mL	$0.57 /mL
Type	RX	RX
Active ingredient	MORPHINE SULFATE	HYDROMORPHONE HYDROCHLORIDE
Manufacturer	Hikma	Specgx LLC
Dosage forms	Injectable, Solution	Tablet, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	Boxed warning	None
Half-life	about 2 hours	about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid
Treats	Dyspnea, Intractable Pain	Cough, Postoperative Pain

duramorph pf exalgo

Rating

70/100

Pharmacy pays

$2.61 /mL

$0.57 /mL

Type

Active ingredient

MORPHINE SULFATE

HYDROMORPHONE HYDROCHLORIDE

Manufacturer

Hikma

Specgx LLC

Dosage forms

Injectable, Solution

Tablet, extended release

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 2 hours

about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid

Treats

Dyspnea, Intractable Pain

Cough, Postoperative Pain

Frequently asked questions

Which is better-rated, Duramorph Pf or Exalgo?

Duramorph Pf and Exalgo are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Duramorph Pf or Exalgo?

Exalgo costs pharmacies less to acquire — about $0.57 vs $2.61 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Duramorph Pf and Exalgo?

Duramorph Pf contains Morphine Sulfate, while Exalgo contains Hydromorphone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.