DURAGESIC-75 vs RYZOLT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. DURAGESIC-75 and RYZOLT are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DURAGESIC-75	RYZOLT
Rating	70/100	New
Pharmacy pays	$9.51 /mL	~$0.72 /30
Type	RX	RX
Active ingredient	FENTANYL	TRAMADOL HYDROCHLORIDE
Manufacturer	Janssen Pharms	Purdue Pharma
Dosage forms	Film, extended release	Tablet, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	—	about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)
Treats	Pain	Pain

duragesic-75 ryzolt

Rating

70/100

New

Pharmacy pays

$9.51 /mL

~$0.72 /30

Type

Active ingredient

FENTANYL

TRAMADOL HYDROCHLORIDE

Manufacturer

Janssen Pharms

Purdue Pharma

Dosage forms

Film, extended release

Tablet, extended release

Drug class

Opioid Agonist

Boxed warning

None

Half-life

—

about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)

Treats

Pain

Frequently asked questions

What is the difference between Duragesic-75 and Ryzolt?

Duragesic-75 contains Fentanyl, while Ryzolt contains Tramadol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.