DURAGESIC-75 vs OPANA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. DURAGESIC-75 and OPANA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DURAGESIC-75	OPANA
Rating	70/100	72/100
Pharmacy pays	$9.51 /mL	~$36.74 /30
Type	RX	RX
Active ingredient	FENTANYL	OXYMORPHONE HYDROCHLORIDE
Manufacturer	Janssen Pharms	Endo Pharms
Dosage forms	Film, extended release	Tablet, Injectable
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Treats	Pain	Pain

duragesic-75 opana

Rating

70/100

72/100

Pharmacy pays

$9.51 /mL

~$36.74 /30

Type

Active ingredient

FENTANYL

OXYMORPHONE HYDROCHLORIDE

Manufacturer

Janssen Pharms

Endo Pharms

Dosage forms

Film, extended release

Tablet, Injectable

Drug class

Opioid Agonist

Boxed warning

None

Treats

Pain

Frequently asked questions

Which is better-rated, Duragesic-75 or Opana?

By our independent rating, Opana scores higher — 3.6 vs 3.5 out of 5 for Duragesic-75. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Duragesic-75 and Opana?

Duragesic-75 contains Fentanyl, while Opana contains Oxymorphone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.