DURAGESIC-50 vs VANTRELA ER

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. DURAGESIC-50 and VANTRELA ER are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DURAGESIC-50	VANTRELA ER
Rating	70/100	New
Pharmacy pays	$9.51 /mL	~$239.83 /30
Type	RX	RX
Active ingredient	FENTANYL	HYDROCODONE BITARTRATE
Manufacturer	Janssen Pharms	Teva Branded Pharm
Dosage forms	Film, extended release	Tablet, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	—	about 3.8 hours (3.8 ± 0.3 hours)
Treats	Pain	Cough, Obstructive Lung Diseases, Postoperative Pain

duragesic-50 vantrela er

Rating

70/100

New

Pharmacy pays

$9.51 /mL

~$239.83 /30

Type

Active ingredient

FENTANYL

HYDROCODONE BITARTRATE

Manufacturer

Janssen Pharms

Teva Branded Pharm

Dosage forms

Film, extended release

Tablet, extended release

Drug class

Opioid Agonist

Boxed warning

None

Half-life

—

about 3.8 hours (3.8 ± 0.3 hours)

Treats

Pain

Cough, Obstructive Lung Diseases, Postoperative Pain

Frequently asked questions

What is the difference between Duragesic-50 and Vantrela ER?

Duragesic-50 contains Fentanyl, while Vantrela ER contains Hydrocodone Bitartrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.