DURAGESIC-50 vs ULTRAM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. DURAGESIC-50 and ULTRAM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DURAGESIC-50	ULTRAM
Rating	70/100	70/100
Pharmacy pays	$9.51 /mL	~$0.72 /30
Type	RX	RX
Active ingredient	FENTANYL	TRAMADOL HYDROCHLORIDE
Manufacturer	Janssen Pharms	Janssen Pharms
Dosage forms	Film, extended release	Tablet
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	—	about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)
Treats	Pain	Pain

duragesic-50 ultram

Rating

70/100

Pharmacy pays

$9.51 /mL

~$0.72 /30

Type

Active ingredient

FENTANYL

TRAMADOL HYDROCHLORIDE

Manufacturer

Janssen Pharms

Dosage forms

Film, extended release

Tablet

Drug class

Opioid Agonist

Boxed warning

None

Half-life

—

about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)

Treats

Pain

Frequently asked questions

Which is better-rated, Duragesic-50 or Ultram?

Duragesic-50 and Ultram are tied at 3.5 out of 5 by our independent rating.

What is the difference between Duragesic-50 and Ultram?

Duragesic-50 contains Fentanyl, while Ultram contains Tramadol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.