Skip to content
ppharmaranks
Menu

DURAGESIC-37 vs LOPERAMIDE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. DURAGESIC-37 and LOPERAMIDE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
70/100

Pharmacy pays

$9.51 /mL
$0.05 /mL

Type

RX
RX

Active ingredient

FENTANYL
LOPERAMIDE HYDROCHLORIDE

Dosage forms

Film, extended release
Capsule

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

Half-life

about 10.8 hours (range 9.1 to 14.4 hours)

Treats

Pain
Functional Colonic Diseases, Diarrhea, Bacillary Dysentery

Frequently asked questions

Which is better-rated, Duragesic-37 or Loperamide Hydrochloride?

Duragesic-37 and Loperamide Hydrochloride are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Duragesic-37 or Loperamide Hydrochloride?

Loperamide Hydrochloride costs pharmacies less to acquire — about $0.05 vs $9.51 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Duragesic-37 and Loperamide Hydrochloride?

Duragesic-37 contains Fentanyl, while Loperamide Hydrochloride contains Loperamide Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.