DURAGESIC-25 vs TAPENTADOL HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. DURAGESIC-25 and TAPENTADOL HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DURAGESIC-25	TAPENTADOL HYDROCHLORIDE
Rating	70/100	New
Pharmacy pays	$9.51 /mL	~$335.93 /30
Type	RX	RX
Active ingredient	FENTANYL	TAPENTADOL HYDROCHLORIDE
Manufacturer	Janssen Pharms	Humanwell
Dosage forms	Film, extended release	Tablet
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	Boxed warning
Half-life	—	about 5 hours (terminal half-life, on average, after oral administration)
Treats	Pain	Pain

duragesic-25 tapentadol hydrochloride

Rating

70/100

New

Pharmacy pays

$9.51 /mL

~$335.93 /30

Type

Active ingredient

FENTANYL

TAPENTADOL HYDROCHLORIDE

Manufacturer

Janssen Pharms

Humanwell

Dosage forms

Film, extended release

Tablet

Drug class

Opioid Agonist

Boxed warning

None

Boxed warning

Half-life

—

about 5 hours (terminal half-life, on average, after oral administration)

Treats

Pain

Frequently asked questions

What is the difference between Duragesic-25 and Tapentadol Hydrochloride?

Duragesic-25 contains Fentanyl, while Tapentadol Hydrochloride contains Tapentadol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.