DURAGESIC-25 vs NUCYNTA ER

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 14, 2026·How we rate

Possible drug interaction. DURAGESIC-25 and NUCYNTA ER are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DURAGESIC-25	NUCYNTA ER
Rating	70/100	New
Pharmacy pays	$9.51 /mL	~$342.56 /30
Type	RX	RX
Active ingredient	FENTANYL	TAPENTADOL HYDROCHLORIDE
Manufacturer	Janssen Pharms	Collegium Pharm Inc
Dosage forms	Film, extended release	Tablet, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	Boxed warning
Half-life	—	about 5 hours (terminal half-life, on average, after oral administration)
Treats	Pain	Pain

duragesic-25 nucynta er

Rating

70/100

New

Pharmacy pays

$9.51 /mL

~$342.56 /30

Type

Active ingredient

FENTANYL

TAPENTADOL HYDROCHLORIDE

Manufacturer

Janssen Pharms

Collegium Pharm Inc

Dosage forms

Film, extended release

Tablet, extended release

Drug class

Opioid Agonist

Boxed warning

None

Boxed warning

Half-life

—

about 5 hours (terminal half-life, on average, after oral administration)

Treats

Pain

Frequently asked questions

What is the difference between Duragesic-25 and Nucynta ER?

Duragesic-25 contains Fentanyl, while Nucynta ER contains Tapentadol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.