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DURAGESIC-25 vs DURAMORPH PF

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. DURAGESIC-25 and DURAMORPH PF are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
70/100

Pharmacy pays

$9.51 /mL
$2.61 /mL

Type

RX
RX

Active ingredient

FENTANYL
MORPHINE SULFATE

Dosage forms

Film, extended release
Injectable, Solution

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

Half-life

about 2 hours

Treats

Pain
Dyspnea, Intractable Pain

Frequently asked questions

Which is better-rated, Duragesic-25 or Duramorph Pf?

Duragesic-25 and Duramorph Pf are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Duragesic-25 or Duramorph Pf?

Duramorph Pf costs pharmacies less to acquire — about $2.61 vs $9.51 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Duragesic-25 and Duramorph Pf?

Duragesic-25 contains Fentanyl, while Duramorph Pf contains Morphine Sulfate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.