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DURAGESIC-12 vs OXYCODONE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. DURAGESIC-12 and OXYCODONE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
70/100

Pharmacy pays

$9.51 /mL
$0.08 /mL

Type

RX
RX

Active ingredient

FENTANYL
OXYCODONE HYDROCHLORIDE

Dosage forms

Film, extended release
Solution, Tablet, Tablet, extended release

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

None
None

Half-life

about 3.5 to 4 hours

Treats

Pain
Postoperative Pain

Frequently asked questions

Which is better-rated, Duragesic-12 or Oxycodone Hydrochloride?

Duragesic-12 and Oxycodone Hydrochloride are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Duragesic-12 or Oxycodone Hydrochloride?

Oxycodone Hydrochloride costs pharmacies less to acquire — about $0.08 vs $9.51 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Duragesic-12 and Oxycodone Hydrochloride?

Duragesic-12 contains Fentanyl, while Oxycodone Hydrochloride contains Oxycodone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.