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DURAGESIC-100 vs SUBLIMAZE PRESERVATIVE FREE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. DURAGESIC-100 and SUBLIMAZE PRESERVATIVE FREE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
72/100

Pharmacy pays

$9.51 /mL
$9.51 /mL

Type

RX
RX

Active ingredient

FENTANYL
FENTANYL CITRATE

Dosage forms

Film, extended release
Injectable

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

None
None

Treats

Pain
Pain

Frequently asked questions

Which is better-rated, Duragesic-100 or Sublimaze Preservative Free?

By our independent rating, Sublimaze Preservative Free scores higher — 3.6 vs 3.5 out of 5 for Duragesic-100. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Duragesic-100 or Sublimaze Preservative Free?

Pharmacies pay about the same to acquire either one — roughly $9.51 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Duragesic-100 and Sublimaze Preservative Free?

Duragesic-100 contains Fentanyl, while Sublimaze Preservative Free contains Fentanyl Citrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.