DURACLON vs ONTRALFY

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 15, 2026·How we rate

Possible drug interaction. DURACLON and ONTRALFY are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DURACLON	ONTRALFY
Rating	68/100	New
Pharmacy pays	~$1.05 /30	~$1.00 /30
Type	RX	RX
Active ingredient	CLONIDINE HYDROCHLORIDE	TIZANIDINE HYDROCHLORIDE
Manufacturer	Mylan Institutional	Fidelity Biopharma
Dosage forms	Injectable	Solution
Drug class	Central Alpha-2 Adrenergic Agonist	Central Alpha-2 Adrenergic Agonist
Boxed warning	Boxed warning	None
Half-life	about 12 to 16 hours	about 2.5 hours
Treats	Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea	Muscle Cramp, Muscle Rigidity, Muscle Spasticity

duraclon ontralfy

Rating

68/100

New

Pharmacy pays

~$1.05 /30

~$1.00 /30

Type

Active ingredient

CLONIDINE HYDROCHLORIDE

TIZANIDINE HYDROCHLORIDE

Manufacturer

Mylan Institutional

Fidelity Biopharma

Dosage forms

Injectable

Solution

Drug class

Central Alpha-2 Adrenergic Agonist

Boxed warning

None

Half-life

about 12 to 16 hours

about 2.5 hours

Treats

Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea

Muscle Cramp, Muscle Rigidity, Muscle Spasticity

Frequently asked questions

Which is cheaper, Duraclon or Ontralfy?

Ontralfy costs pharmacies less to acquire — about $1.00 vs $1.05 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Duraclon and Ontralfy?

Duraclon contains Clonidine Hydrochloride, while Ontralfy contains Tizanidine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.