DUOPA vs SINEMET CR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 6, 2026·How we rate

Attribute	DUOPA	SINEMET CR
Rating	70/100	72/100
Pharmacy pays	~$20.52 /30	~$20.52 /30
Type	RX	RX
Active ingredient	CARBIDOPA AND LEVODOPA	CARBIDOPA AND LEVODOPA
Manufacturer	Abbvie	Organon
Dosage forms	Suspension	Tablet, extended release
Drug class	—	—
Boxed warning	None	None
Half-life	about 50 minutes (extended to about 1.5 hours when taken with carbidopa)	about 50 minutes (extended to about 1.5 hours when taken with carbidopa)

duopa sinemet cr

Rating

70/100

72/100

Pharmacy pays

~$20.52 /30

Type

Active ingredient

CARBIDOPA AND LEVODOPA

Manufacturer

Abbvie

Organon

Dosage forms

Suspension

Tablet, extended release

Drug class

—

Boxed warning

None

Half-life

about 50 minutes (extended to about 1.5 hours when taken with carbidopa)

Frequently asked questions

Which is better-rated, Duopa or Sinemet CR?

By our independent rating, Sinemet CR scores higher — 3.6 vs 3.5 out of 5 for Duopa. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Duopa or Sinemet CR?

Pharmacies pay about the same to acquire either one — roughly $20.52 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Duopa and Sinemet CR?

Both Duopa and Sinemet CR share the active ingredient Carbidopa and Levodopa.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.