DRISDOL vs RAYALDEE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. DRISDOL and RAYALDEE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DRISDOL	RAYALDEE
Rating	New	New
Pharmacy pays	~$3.48 /30	—
Type	RX	RX
Active ingredient	ERGOCALCIFEROL	CALCIFEDIOL
Manufacturer	Esjay Pharma	Eirgen
Dosage forms	Capsule	Capsule, extended release
Drug class	Provitamin D2 Compound	Vitamin D3 Analog
Boxed warning	None	None
Treats	Hypoparathyroidism, Rickets, Hypophosphatemia	Hypocalcemia, Hypoparathyroidism, Osteoporosis

drisdol rayaldee

Rating

New

Pharmacy pays

~$3.48 /30

—

Type

Active ingredient

ERGOCALCIFEROL

CALCIFEDIOL

Manufacturer

Esjay Pharma

Eirgen

Dosage forms

Capsule

Capsule, extended release

Drug class

Provitamin D2 Compound

Vitamin D3 Analog

Boxed warning

None

Treats

Hypoparathyroidism, Rickets, Hypophosphatemia

Hypocalcemia, Hypoparathyroidism, Osteoporosis

Frequently asked questions

What is the difference between Drisdol and Rayaldee?

Drisdol contains Ergocalciferol, while Rayaldee contains Calcifediol — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.