DOXEPIN HYDROCHLORIDE vs TOFRANIL-PM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 14, 2026·How we rate

Possible drug interaction. DOXEPIN HYDROCHLORIDE and TOFRANIL-PM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DOXEPIN HYDROCHLORIDE	TOFRANIL-PM
Rating	70/100	70/100
Pharmacy pays	~$4.84 /30	~$100.18 /30
Type	RX	RX
Active ingredient	DOXEPIN HYDROCHLORIDE	IMIPRAMINE PAMOATE
Manufacturer	Watson Labs	Specgx LLC
Dosage forms	Capsule, Topical, Solution, Tablet	Capsule
Drug class	Tricyclic Antidepressant	Tricyclic Antidepressant
Boxed warning	None	None
Half-life	about 8 to 24 hours (average about 17 hours)	—
Treats	Anxiety Disorders, Depressive Disorder, Atopic Dermatitis	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis

doxepin hydrochloride tofranil-pm

Rating

70/100

Pharmacy pays

~$4.84 /30

~$100.18 /30

Type

Active ingredient

DOXEPIN HYDROCHLORIDE

IMIPRAMINE PAMOATE

Manufacturer

Watson Labs

Specgx LLC

Dosage forms

Capsule, Topical, Solution, Tablet

Capsule

Drug class

Tricyclic Antidepressant

Boxed warning

None

Half-life

about 8 to 24 hours (average about 17 hours)

—

Treats

Anxiety Disorders, Depressive Disorder, Atopic Dermatitis

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis

Get doxepin hydrochloridehigher-rated option

Advertising disclosure: Some links are affiliate links. We may earn a commission at no extra cost to you. This never affects our independent ratings.

Get treatment online

Licensed online providers — consult & get prescribed if eligible.

SesameCompare online visit prices

Frequently asked questions

Which is better-rated, Doxepin Hydrochloride or Tofranil-Pm?

Doxepin Hydrochloride and Tofranil-Pm are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Doxepin Hydrochloride or Tofranil-Pm?

Doxepin Hydrochloride costs pharmacies less to acquire — about $4.84 vs $100.18 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Doxepin Hydrochloride and Tofranil-Pm?

Doxepin Hydrochloride contains Doxepin Hydrochloride, while Tofranil-Pm contains Imipramine Pamoate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.