DOXEPIN HYDROCHLORIDE vs PAMELOR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 8, 2026·How we rate

Possible drug interaction. DOXEPIN HYDROCHLORIDE and PAMELOR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DOXEPIN HYDROCHLORIDE	PAMELOR
Rating	72/100	70/100
Pharmacy pays	~$4.84 /30	$0.16 /mL
Type	RX	RX
Active ingredient	DOXEPIN HYDROCHLORIDE	NORTRIPTYLINE HYDROCHLORIDE
Manufacturer	Watson Labs	Specgx LLC
Dosage forms	Capsule, Topical, Solution, Tablet	Capsule
Drug class	Tricyclic Antidepressant	Tricyclic Antidepressant
Boxed warning	None	None
Half-life	about 8 to 24 hours (average about 17 hours)	—
Treats	Anxiety Disorders, Depressive Disorder, Atopic Dermatitis	Anxiety Disorders, Attention Deficit Disorder with Hyperactivity, Depressive Disorder

doxepin hydrochloride pamelor

Rating

72/100

70/100

Pharmacy pays

~$4.84 /30

$0.16 /mL

Type

Active ingredient

DOXEPIN HYDROCHLORIDE

NORTRIPTYLINE HYDROCHLORIDE

Manufacturer

Watson Labs

Specgx LLC

Dosage forms

Capsule, Topical, Solution, Tablet

Capsule

Drug class

Tricyclic Antidepressant

Boxed warning

None

Half-life

about 8 to 24 hours (average about 17 hours)

—

Treats

Anxiety Disorders, Depressive Disorder, Atopic Dermatitis

Anxiety Disorders, Attention Deficit Disorder with Hyperactivity, Depressive Disorder

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Frequently asked questions

Which is better-rated, Doxepin Hydrochloride or Pamelor?

By our independent rating, Doxepin Hydrochloride scores higher — 3.6 vs 3.5 out of 5 for Pamelor. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Doxepin Hydrochloride and Pamelor?

Doxepin Hydrochloride contains Doxepin Hydrochloride, while Pamelor contains Nortriptyline Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.