DONEPEZIL HYDROCHLORIDE vs MEMANTINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. DONEPEZIL HYDROCHLORIDE and MEMANTINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DONEPEZIL HYDROCHLORIDE	MEMANTINE HYDROCHLORIDE
Rating	70/100	New
Pharmacy pays	~$1.43 /30	~$2.46 /30
Type	RX	RX
Active ingredient	DONEPEZIL HYDROCHLORIDE	MEMANTINE HYDROCHLORIDE
Manufacturer	Novitium Pharma	Vitruvias
Dosage forms	Tablet	Capsule, extended release, Kit, Tablet
Drug class	Cholinesterase Inhibitor	N-Methyl-D-Aspartate Receptor Antagonist
Boxed warning	None	None
Half-life	about 70 hours	about 60 to 80 hours
Treats	Alzheimer Disease	Alzheimer Disease

donepezil hydrochloride memantine hydrochloride

Rating

70/100

New

Pharmacy pays

~$1.43 /30

~$2.46 /30

Type

Active ingredient

DONEPEZIL HYDROCHLORIDE

MEMANTINE HYDROCHLORIDE

Manufacturer

Novitium Pharma

Vitruvias

Dosage forms

Tablet

Capsule, extended release, Kit, Tablet

Drug class

Cholinesterase Inhibitor

N-Methyl-D-Aspartate Receptor Antagonist

Boxed warning

None

Half-life

about 70 hours

about 60 to 80 hours

Treats

Alzheimer Disease

Frequently asked questions

Which is cheaper, Donepezil Hydrochloride or Memantine Hydrochloride?

Donepezil Hydrochloride costs pharmacies less to acquire — about $1.43 vs $2.46 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Donepezil Hydrochloride and Memantine Hydrochloride?

Donepezil Hydrochloride contains Donepezil Hydrochloride, while Memantine Hydrochloride contains Memantine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.