DOLOPHINE HYDROCHLORIDE vs OXYCONTIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. DOLOPHINE HYDROCHLORIDE and OXYCONTIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DOLOPHINE HYDROCHLORIDE	OXYCONTIN
Rating	72/100	New
Pharmacy pays	$0.18 /mL	$0.08 /mL
Type	RX	RX
Active ingredient	METHADONE HYDROCHLORIDE	OXYCODONE HYDROCHLORIDE
Manufacturer	Hikma	Knoa Pharma
Dosage forms	Tablet, Syrup	Tablet, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	Boxed warning
Half-life	about 8 to 59 hours (terminal/elimination half-life; a very wide range)	about 3.5 to 4 hours
Treats	Opioid-Related Disorders, Intractable Pain	Postoperative Pain

dolophine hydrochloride oxycontin

Rating

72/100

New

Pharmacy pays

$0.18 /mL

$0.08 /mL

Type

Active ingredient

METHADONE HYDROCHLORIDE

OXYCODONE HYDROCHLORIDE

Manufacturer

Hikma

Knoa Pharma

Dosage forms

Tablet, Syrup

Tablet, extended release

Drug class

Opioid Agonist

Boxed warning

None

Boxed warning

Half-life

about 8 to 59 hours (terminal/elimination half-life; a very wide range)

about 3.5 to 4 hours

Treats

Opioid-Related Disorders, Intractable Pain

Postoperative Pain

Frequently asked questions

Which is cheaper, Dolophine Hydrochloride or Oxycontin?

Oxycontin costs pharmacies less to acquire — about $0.08 vs $0.18 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Dolophine Hydrochloride and Oxycontin?

Dolophine Hydrochloride contains Methadone Hydrochloride, while Oxycontin contains Oxycodone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.