DOLOPHINE HYDROCHLORIDE vs METHADONE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Attribute	DOLOPHINE HYDROCHLORIDE	METHADONE HYDROCHLORIDE
Rating	72/100	72/100
Pharmacy pays	$0.18 /mL	$0.18 /mL
Type	RX	RX
Active ingredient	METHADONE HYDROCHLORIDE	METHADONE HYDROCHLORIDE
Manufacturer	Hikma	Hikma
Dosage forms	Tablet, Syrup	Injectable, Solution, Tablet
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	Boxed warning
Half-life	about 8 to 59 hours (terminal/elimination half-life; a very wide range)	about 8 to 59 hours (terminal/elimination half-life; a very wide range)
Treats	Opioid-Related Disorders, Intractable Pain	Opioid-Related Disorders, Intractable Pain

dolophine hydrochloride methadone hydrochloride

Rating

72/100

Pharmacy pays

$0.18 /mL

Type

Active ingredient

METHADONE HYDROCHLORIDE

Manufacturer

Hikma

Dosage forms

Tablet, Syrup

Injectable, Solution, Tablet

Drug class

Opioid Agonist

Boxed warning

None

Boxed warning

Half-life

about 8 to 59 hours (terminal/elimination half-life; a very wide range)

Treats

Opioid-Related Disorders, Intractable Pain

Frequently asked questions

Which is better-rated, Dolophine Hydrochloride or Methadone Hydrochloride?

Dolophine Hydrochloride and Methadone Hydrochloride are tied at 3.6 out of 5 by our independent rating.

Which is cheaper, Dolophine Hydrochloride or Methadone Hydrochloride?

Pharmacies pay about the same to acquire either one — roughly $0.18 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Dolophine Hydrochloride and Methadone Hydrochloride?

Both Dolophine Hydrochloride and Methadone Hydrochloride share the active ingredient Methadone Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.