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DOLOPHINE HYDROCHLORIDE vs HYDROMORPHONE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. DOLOPHINE HYDROCHLORIDE and HYDROMORPHONE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

dolophine hydrochloridehydromorphone hydrochloride

Rating

72/100
44/100

Pharmacy pays

$0.18 /mL
$0.57 /mL

Type

RX
RX

Active ingredient

METHADONE HYDROCHLORIDE
HYDROMORPHONE HYDROCHLORIDE

Manufacturer

Hikma
Hospira

Dosage forms

Tablet, Syrup
Suppository, Tablet

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

None
Boxed warning

Half-life

about 8 to 59 hours (terminal/elimination half-life; a very wide range)
about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid

Treats

Opioid-Related Disorders, Intractable Pain
Cough, Postoperative Pain

Frequently asked questions

Which is better-rated, Dolophine Hydrochloride or Hydromorphone Hydrochloride?

By our independent rating, Dolophine Hydrochloride scores higher — 3.6 vs 2.2 out of 5 for Hydromorphone Hydrochloride. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Dolophine Hydrochloride or Hydromorphone Hydrochloride?

Dolophine Hydrochloride costs pharmacies less to acquire — about $0.18 vs $0.57 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Dolophine Hydrochloride and Hydromorphone Hydrochloride?

Dolophine Hydrochloride contains Methadone Hydrochloride, while Hydromorphone Hydrochloride contains Hydromorphone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.