DOLOPHINE HYDROCHLORIDE vs EXALGO

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. DOLOPHINE HYDROCHLORIDE and EXALGO are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DOLOPHINE HYDROCHLORIDE	EXALGO
Rating	72/100	70/100
Pharmacy pays	$0.18 /mL	$0.57 /mL
Type	RX	RX
Active ingredient	METHADONE HYDROCHLORIDE	HYDROMORPHONE HYDROCHLORIDE
Manufacturer	Hikma	Specgx LLC
Dosage forms	Tablet, Syrup	Tablet, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	about 8 to 59 hours (terminal/elimination half-life; a very wide range)	about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid
Treats	Opioid-Related Disorders, Intractable Pain	Cough, Postoperative Pain

dolophine hydrochloride exalgo

Rating

72/100

70/100

Pharmacy pays

$0.18 /mL

$0.57 /mL

Type

Active ingredient

METHADONE HYDROCHLORIDE

HYDROMORPHONE HYDROCHLORIDE

Manufacturer

Hikma

Specgx LLC

Dosage forms

Tablet, Syrup

Tablet, extended release

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 8 to 59 hours (terminal/elimination half-life; a very wide range)

about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid

Treats

Opioid-Related Disorders, Intractable Pain

Cough, Postoperative Pain

Frequently asked questions

Which is better-rated, Dolophine Hydrochloride or Exalgo?

By our independent rating, Dolophine Hydrochloride scores higher — 3.6 vs 3.5 out of 5 for Exalgo. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Dolophine Hydrochloride or Exalgo?

Dolophine Hydrochloride costs pharmacies less to acquire — about $0.18 vs $0.57 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Dolophine Hydrochloride and Exalgo?

Dolophine Hydrochloride contains Methadone Hydrochloride, while Exalgo contains Hydromorphone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.