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DOLOPHINE HYDROCHLORIDE vs DURAGESIC-12

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. DOLOPHINE HYDROCHLORIDE and DURAGESIC-12 are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

72/100
70/100

Pharmacy pays

$0.18 /mL
$9.51 /mL

Type

RX
RX

Active ingredient

METHADONE HYDROCHLORIDE
FENTANYL

Dosage forms

Tablet, Syrup
Film, extended release

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

None
None

Half-life

about 8 to 59 hours (terminal/elimination half-life; a very wide range)

Treats

Opioid-Related Disorders, Intractable Pain
Pain

Frequently asked questions

Which is better-rated, Dolophine Hydrochloride or Duragesic-12?

By our independent rating, Dolophine Hydrochloride scores higher — 3.6 vs 3.5 out of 5 for Duragesic-12. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Dolophine Hydrochloride or Duragesic-12?

Dolophine Hydrochloride costs pharmacies less to acquire — about $0.18 vs $9.51 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Dolophine Hydrochloride and Duragesic-12?

Dolophine Hydrochloride contains Methadone Hydrochloride, while Duragesic-12 contains Fentanyl — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.